By Karl Maramorosch
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Extra resources for Advances in cell culture. Volume 2
Lung fibroblasts of adult origin showed enzyme activities similar to those of the oldest WI-38 cultures. Macieira-Coelho and Lima (1973) have reported t h a t acid phosphatase increases in these cells only when they are close to the end of their life span. An increase in lysosomal enzyme activity during successive passages of WI-38 cells without change in immunochemical specificity has been reported (Choe and Rose, 1976). , 1969; Vladutiu and Rose, 1974). Thermostability of two lysosomal enzymes, α-glucosidase and iV-acetyl-ß-glucosaminidase, showed no change in WI-38 cells from passage 22 to 43 (Houben and Remade, 1976, 1978).
Additional stochastic hypotheses which may be applied to cellular aging include the somatic mutation hypothesis (Crowley and Curtis, 1963), the free radical hypothesis (Harmon, 1956), and the cross-linking hypothesis (Bjorksten, 1963). Burnet (1977) has more recently proposed the intrinsic mutagenesis hypothesis in an attempt to link the deterministic and the stochastic hypotheses. He suggests t h a t the mutability of key polymerases leading to error accumulation may be under genetic control. VII.
1973,1974) have reported that normal human skin fibroblasts show decreased repair of 7-ray-induced DNA chain breaks with increasing in vitro age. A similar finding of decreased repair in progeria cells by this group has not been confirmed (Regan and Setlow, 1974). Brown et al. (1976) have found t h a t an increased rate of DNA repair could be induced in a progeria cell line following 7-irradiation by cocultivating these cells with an established hamster cell line, a midpassage normal h u m a n diploid line, or a second progeria line.
Advances in cell culture. Volume 2 by Karl Maramorosch