By Victoria Lacroix
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The most common human vaccine is the trivalent influenza vaccine that contains purified and inactivated material from three viral strains. Typically this vaccine includes material from two influenza A virus subtypes and one influenza B virus strain. A vaccine formulated for one year may be ineffective in the following year, since the influenza virus changes rapidly over time and different strains become dominant. Antiviral drugs can be used to treat influenza, with neuraminidase inhibitors being particularly effective.
Second cholera pandemic Hand bill from the New York City Board of Health, 1832. The outdated public health advice demonstrates the lack of understanding of the disease and its actual causative factors. The second cholera pandemic also known as the Asiatic Cholera Pandemic was a Cholera pandemic from 1829-1849. This pandemic began, like the first, with outbreaks along the Ganges River delta. From there the disease spread along trade routes to cover most of India. By 1828 the disease had traveled to China and was at the southern tips of the Ural Mountains in 1829.
How many mutations would make an avian virus capable of infecting humans efficiently, or how many mutations would render an influenza virus a pandemic strain, is difficult to predict. We have examined sequences from the 1918 strain, which is the only pandemic influenza virus that could be entirely derived from avian strains. Of the 52 species-associated positions, 16 have residues typical for human strains; the others remained as avian signatures. " Highly pathogenic H5N1 avian influenza kills 50% of humans that catch it.
All About Pandemics (Epidemic of Infectious Disease) by Victoria Lacroix